19.06.2005, 21:12
ORIGINAL RESEARCH COMMUNICATION
http://www.ajcn.org/cgi/content/abstract/81/5/1168
Effects of school milk intervention on cortical bone accretion and indicators relevant to bone metabolism in Chinese girls aged 10–12 y in Beijing1,2,3
Kun Zhu, Xueqin Du, Chris T Cowell, Heather Greenfield, Barbara Blades, Timothy A Dobbins, Qian Zhang and David R Fraser
From the Faculty of Veterinary Science (KZ, XD, HG, and DRF) and the School of Public Health (TAD), University of Sydney, Sydney, Australia; the Institute of Endocrinology and Diabetes, Children's Hospital at Westmead, Westmead, Australia (CTC and BB); and the Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, China (QZ)
Background: We previously reported that increased milk consumption enhances growth and bone mineral accretion in Chinese girls aged 10–12 y.
Objective: Our objective was to evaluate the effects of milk supplementation on cortical bone accretion and to study the physiologic mechanisms underlying the observed changes in bone.
Design: Chinese girls aged 10 y were randomly assigned into calcium-fortified milk (Ca milk), calcium and vitamin D–fortified milk (CaD milk), and control groups according to their schools in a 24-mo school milk intervention trial. Periosteal and medullary diameters of metacarpal bone were measured at baseline and 24 mo in the Ca milk (n = 177), CaD milk (n = 210), and control (n = 219) groups. Insulin-like growth factor I (IGF-I), parathyroid hormone (PTH), bone alkaline phosphatase (BAP), osteocalcin, and deoxypyridinoline concentrations were measured at baseline and at 12 and 24 mo in the Ca milk (n = 43), CaD milk (n = 44), and control (n = 41) groups.
Results: After adjustment for pubertal status and clustering by school, 24-mo supplementation led to greater increases in periosteal diameter (1.2%) and cortical thickness (5.7%) and to smaller gains in medullary diameter (6.7%) than did the control (P < 0.05). The CaD milk group had lower serum BAP at 12 mo (19.9%) and lower serum PTH at 12 (46.2%) and 24 (16.4%) mo than did the control group (P < 0.05). The effect of milk supplementation on increasing IGF-I concentrations at 24 mo (16.7–23.3%) was significant in individual analyses but not after adjustment for clustering by school.
Conclusions: Milk supplementation showed positive effects on periosteal and endosteal apposition of cortical bone.
Key Words: Fortified milk • Chinese girls • cortical bone accretion • bone alkaline phosphatase • insulin-like growth factor I
:evil: Das Letzte – oder doch eher „Allerletzte“?????
Hier beschreiben australische „Forscher“ voll Begeisterung, dass ein Schulmilch-Programm in Peking über 2 Jahre „positive Effekte“ auf die Knochen von 10- 12jährigen Schulmädchen hatte........
Erwähnt werden nicht mögliche „weniger schöne“ Effekte – wie vielleicht Gewichtszunahme
Siehe
>> Chinas fette Jahre
Steigender Wohlstand lässt Bäuche wachsen <<
http://www.lebensmittelallergie.info/thr...age=3&sid= ( letzte Seite....)
..............
Ist den „Forschern“ nicht bekannt :
LI-und ethnische Gruppen
Asians : 95 to 100% lactase -malabsorbers
http://www.ncbi.nlm.nih.gov/entrez/query...ds=6235167
Prevalence of primary adult lactose malabsorption in three populations of northern China.
Wang YG, Yan YS, Xu JJ, Du RF, Flatz SD, Kuhnau W, Flatz G.
Lactose absorption capacity was examined in 641 apparently healthy adolescents and adults (447 males and 194 females with an average age of 22.9 years and an age range of 16-46 years) using a field version of the lactose tolerance test with breath hydrogen determination. In the total sample, 89 lactose absorbers and 552 lactose malabsorbers were identified. Lactose malabsorption was most frequent in a subgroup of Han (Chinese) from northeastern China (229 of 248 subjects, 92.3%). Among 198 Mongols from Inner Mongolia, there were 174 lactose malabsorbers (87.9% ). The frequency of lactose malabsorption was lowest in a group of Kazakhs, traditional herders from the northwestern region of Xinjiang (149 of 195 subjects, 76.4% )………..
Oder hier :
Chin Med J (Engl). 2000 Dec;113(12):1129-32. Related Articles, Links
The prevalence of lactase deficiency and lactose intolerance in Chinese children of different ages.
Yang Y, He M, Cui H, Bian L, Wang Z.
RESULTS: LD occurred in 38.5% of children in the 3-5 year age group, and 87% of the 7-8 year and 11-13 year old groups. http://www.ncbi.nlm.nih.gov/entrez/query...s=11776151
…und es scheint die “Forscher” auch herzlich wenig zu stören, dass in ihrem eigenen Lande die Ureinwohner unter dieser Laktose schwer zu leiden haben......
1: J Paediatr Child Health. 2003 Jul; 39(5): 381-5.
Carbohydrate intolerance and kidney stones in children in the Goldfields.
Baldwin DN, Spencer JL, Jeffries-Stokes CA.
University of Western Australia, Department of Paediatrics, Rural
Paediatric Unit, Kalgoorlie, Western Australia, Australia.
Renal stones have been reported as a common finding in Australian Aboriginal children.
:::: Nierensteine werden als häufiger ( gewöhnlicher, normaler) Befund bei Kindern der Aboriginis erhoben.
The stones are predominantly urate in
composition. We report on five children with nephrolithiasis from the Goldfields region of Western Australia. All were diagnosed when under
5 years of age, the majority being under 3 years.
:::: Er berichtet von 5 Kindern mit Nierensteinen aus der westlichen "Goldfield-Region"; die alle bis zum 5. Lebensjahr Nierensteine entwickelt hatten- die meisten waren 3 Jahre alt.
All five children also had lactose intolerance,
:::: alle 5 Kinder hatten LI
and we postulate that carbohydrate malabsorption, together with the ensuing chronic diarrhoea and
intraluminal breakdown of sugars by enteric bacteria may result in a situation of chronic metabolic acidosis.
:::: Der Autor stellt hier fest, daß Kohlehydratmalabsorptionen mit den folgenden Durchfällen und der Kohlehydratsynthetisierung durch Bakterien zu einer metabolischen Acidose(Übersäuerung) führen!
Chronic metabolic acidosis can lead to protein catabolism, increased urate excretion and the formation of renal stones.
:::: Chronische Übersäuerung führt zu Eiweißabbau, zunehmender Harnsäureausscheidung und Steinbildung.
Carbohydrate intolerance may be an aetiological actor in the development of renal stones and possibly chronic renal disease, particularly in Aboriginal Australians.
:::: Kohlehydratmalabsorption könnte ( warum könnte??? ist doch so....) bei der Entstehung von Nierensteinen und chronischen Nierenleiden eine wichtige Rolle spielen- vor allem bei den Aboriginis
Renal disease represents one of the most significant factors affecting the health of Australian Aboriginal people.
::::: Nierenleiden sind die häufigsten Erkrankungen der Aboriginis......
The incidence of end stage renal failure in this
population exceeds that of non-Aboriginals by a factor of 13:1, and this disproportionate figure is increasing. It is likely that chronic renal damage is multifactorial; however, it is probable that at least
some aetiological factors have their onset during childhood.
PMID: 12887672
http://www.ncbi.nlm.nih.gov/entrez/query...t=Abstract
Da fällt mir nur ein:
Sponsored by Rabo-Bank
http://www.rabobank.com/Images/rabobank_...25-158.pdf
–und zwar mit diesem Ziel: $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$
Uli :evil:
http://www.ajcn.org/cgi/content/abstract/81/5/1168
Effects of school milk intervention on cortical bone accretion and indicators relevant to bone metabolism in Chinese girls aged 10–12 y in Beijing1,2,3
Kun Zhu, Xueqin Du, Chris T Cowell, Heather Greenfield, Barbara Blades, Timothy A Dobbins, Qian Zhang and David R Fraser
From the Faculty of Veterinary Science (KZ, XD, HG, and DRF) and the School of Public Health (TAD), University of Sydney, Sydney, Australia; the Institute of Endocrinology and Diabetes, Children's Hospital at Westmead, Westmead, Australia (CTC and BB); and the Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, China (QZ)
Background: We previously reported that increased milk consumption enhances growth and bone mineral accretion in Chinese girls aged 10–12 y.
Objective: Our objective was to evaluate the effects of milk supplementation on cortical bone accretion and to study the physiologic mechanisms underlying the observed changes in bone.
Design: Chinese girls aged 10 y were randomly assigned into calcium-fortified milk (Ca milk), calcium and vitamin D–fortified milk (CaD milk), and control groups according to their schools in a 24-mo school milk intervention trial. Periosteal and medullary diameters of metacarpal bone were measured at baseline and 24 mo in the Ca milk (n = 177), CaD milk (n = 210), and control (n = 219) groups. Insulin-like growth factor I (IGF-I), parathyroid hormone (PTH), bone alkaline phosphatase (BAP), osteocalcin, and deoxypyridinoline concentrations were measured at baseline and at 12 and 24 mo in the Ca milk (n = 43), CaD milk (n = 44), and control (n = 41) groups.
Results: After adjustment for pubertal status and clustering by school, 24-mo supplementation led to greater increases in periosteal diameter (1.2%) and cortical thickness (5.7%) and to smaller gains in medullary diameter (6.7%) than did the control (P < 0.05). The CaD milk group had lower serum BAP at 12 mo (19.9%) and lower serum PTH at 12 (46.2%) and 24 (16.4%) mo than did the control group (P < 0.05). The effect of milk supplementation on increasing IGF-I concentrations at 24 mo (16.7–23.3%) was significant in individual analyses but not after adjustment for clustering by school.
Conclusions: Milk supplementation showed positive effects on periosteal and endosteal apposition of cortical bone.
Key Words: Fortified milk • Chinese girls • cortical bone accretion • bone alkaline phosphatase • insulin-like growth factor I
:evil: Das Letzte – oder doch eher „Allerletzte“?????
Hier beschreiben australische „Forscher“ voll Begeisterung, dass ein Schulmilch-Programm in Peking über 2 Jahre „positive Effekte“ auf die Knochen von 10- 12jährigen Schulmädchen hatte........
Erwähnt werden nicht mögliche „weniger schöne“ Effekte – wie vielleicht Gewichtszunahme
Siehe
>> Chinas fette Jahre
Steigender Wohlstand lässt Bäuche wachsen <<
http://www.lebensmittelallergie.info/thr...age=3&sid= ( letzte Seite....)
..............
Ist den „Forschern“ nicht bekannt :
LI-und ethnische Gruppen
Asians : 95 to 100% lactase -malabsorbers
http://www.ncbi.nlm.nih.gov/entrez/query...ds=6235167
Prevalence of primary adult lactose malabsorption in three populations of northern China.
Wang YG, Yan YS, Xu JJ, Du RF, Flatz SD, Kuhnau W, Flatz G.
Lactose absorption capacity was examined in 641 apparently healthy adolescents and adults (447 males and 194 females with an average age of 22.9 years and an age range of 16-46 years) using a field version of the lactose tolerance test with breath hydrogen determination. In the total sample, 89 lactose absorbers and 552 lactose malabsorbers were identified. Lactose malabsorption was most frequent in a subgroup of Han (Chinese) from northeastern China (229 of 248 subjects, 92.3%). Among 198 Mongols from Inner Mongolia, there were 174 lactose malabsorbers (87.9% ). The frequency of lactose malabsorption was lowest in a group of Kazakhs, traditional herders from the northwestern region of Xinjiang (149 of 195 subjects, 76.4% )………..
Oder hier :
Chin Med J (Engl). 2000 Dec;113(12):1129-32. Related Articles, Links
The prevalence of lactase deficiency and lactose intolerance in Chinese children of different ages.
Yang Y, He M, Cui H, Bian L, Wang Z.
RESULTS: LD occurred in 38.5% of children in the 3-5 year age group, and 87% of the 7-8 year and 11-13 year old groups. http://www.ncbi.nlm.nih.gov/entrez/query...s=11776151
…und es scheint die “Forscher” auch herzlich wenig zu stören, dass in ihrem eigenen Lande die Ureinwohner unter dieser Laktose schwer zu leiden haben......
1: J Paediatr Child Health. 2003 Jul; 39(5): 381-5.
Carbohydrate intolerance and kidney stones in children in the Goldfields.
Baldwin DN, Spencer JL, Jeffries-Stokes CA.
University of Western Australia, Department of Paediatrics, Rural
Paediatric Unit, Kalgoorlie, Western Australia, Australia.
Renal stones have been reported as a common finding in Australian Aboriginal children.
:::: Nierensteine werden als häufiger ( gewöhnlicher, normaler) Befund bei Kindern der Aboriginis erhoben.
The stones are predominantly urate in
composition. We report on five children with nephrolithiasis from the Goldfields region of Western Australia. All were diagnosed when under
5 years of age, the majority being under 3 years.
:::: Er berichtet von 5 Kindern mit Nierensteinen aus der westlichen "Goldfield-Region"; die alle bis zum 5. Lebensjahr Nierensteine entwickelt hatten- die meisten waren 3 Jahre alt.
All five children also had lactose intolerance,
:::: alle 5 Kinder hatten LI
and we postulate that carbohydrate malabsorption, together with the ensuing chronic diarrhoea and
intraluminal breakdown of sugars by enteric bacteria may result in a situation of chronic metabolic acidosis.
:::: Der Autor stellt hier fest, daß Kohlehydratmalabsorptionen mit den folgenden Durchfällen und der Kohlehydratsynthetisierung durch Bakterien zu einer metabolischen Acidose(Übersäuerung) führen!
Chronic metabolic acidosis can lead to protein catabolism, increased urate excretion and the formation of renal stones.
:::: Chronische Übersäuerung führt zu Eiweißabbau, zunehmender Harnsäureausscheidung und Steinbildung.
Carbohydrate intolerance may be an aetiological actor in the development of renal stones and possibly chronic renal disease, particularly in Aboriginal Australians.
:::: Kohlehydratmalabsorption könnte ( warum könnte??? ist doch so....) bei der Entstehung von Nierensteinen und chronischen Nierenleiden eine wichtige Rolle spielen- vor allem bei den Aboriginis
Renal disease represents one of the most significant factors affecting the health of Australian Aboriginal people.
::::: Nierenleiden sind die häufigsten Erkrankungen der Aboriginis......
The incidence of end stage renal failure in this
population exceeds that of non-Aboriginals by a factor of 13:1, and this disproportionate figure is increasing. It is likely that chronic renal damage is multifactorial; however, it is probable that at least
some aetiological factors have their onset during childhood.
PMID: 12887672
http://www.ncbi.nlm.nih.gov/entrez/query...t=Abstract
Da fällt mir nur ein:
Sponsored by Rabo-Bank
http://www.rabobank.com/Images/rabobank_...25-158.pdf
–und zwar mit diesem Ziel: $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$
Uli :evil: