Milch lässt Akne blühen

[Uli]

Und weiterhin die Rolle der Milch als „ Initiator und Unterhalter“
der Akne!

Uli

Hautarzt. 2010 Feb;61(2):115-25.
[Acne vulgaris. Role of diet]

[Article in German]

Melnik B.

Fachgebiet Dermatologie, Umweltmedizin und Gesundheitstheorie, Universität Osnabrück, Sedanstr. 115, 49090 Osnabrück. Melnik@t-online.de

The epidemic-like high prevalence of acne of more than 85% of adolescents exposed to westernized life style points to the role of nutritional factors. Insulinotropic foods, especially milk, dairy products and carbohydrates with high glycemic index and smoking lead to pathological exaggeration of already physiologically increased growth factor signaling of puberty. Food-derived growth factors activate the oncogenic phosphoinositide-3-kinase/Akt signaling pathway, which increases androgen receptor transcriptional activity and de-represses FoxO1-suppressed target genes of follicular keratinocyte proliferation and sebaceous lipogenesis. Thus, acne is the visible metabolic syndrome of skin exaggerated by growth factor signaling of westernized malnutrition. These insights allow a new classification of western life style acne as acne alimentaris and provide the rationale for dietary intervention. All efforts should be undertaken to eliminate the insulinotropic effector mechanism of milk in order to reduce the prevalence of acne and even more serious civilization diseases associated with malnutrition-dependent oncogenic signal transduction.

PMID: 20107753 [PubMed - in process]

8: Hautarzt. 2010 Jan 17.
[How acne vulgaris develops.]
[Article in German]

Plewig G.
Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität München, Frauenlobstr. 9-11, 80337, München, Deutschland, Gerd.Plewig@med.uni-muenchen.de.

For the initiation of acne multiple factors are required from endogenous to
exogenous sources. The morphogenesis of acne is well studied, and the principle steps are discussed in the paper. Acne is a disease of humans, developing in sebaceous follicles. The first step is a proliferation-retention hyperkeratosis in the infundibulum, thus forming a follicular filament, from which a microcomedo arises. Finally open and closed comedones appear. This sequence is not strictly followed, but quite typical. Androgen stimulation activates sebaceous lipogenesis. At this point propionibacteria colonize the follicle and comedones. ?At earlier or later stages of the comedo development inflammatory phenomena appear, ranging from subtle to severe. Depending on the amount of inflammation, scars may develop. There is an undisputable genetic component for the initiation ?of acne, as twin studies have shown. The or these genetic factors have not been determined yet. The inflammatory cascade is up-regulated by immunological factors. Exogenous factors, underestimated in the past, seem to play an important role as well, as epidemiological studies and recent publications from different investigators have shown. Nutrition, particularly hyperglycemic food and milk products, are directly involved in the pathogenesis of acne.
PMID: 20084358


http://www.ncbi.nlm.nih.gov/pubmed/

Siehe auch hier:
http://milchlos.de/milos_0777.htm